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Human Swine Flu A(H1N1) - Tamiflu Resistance

 
 
 

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EPFL scientists develop computer tool to identify mutations that make influenza resistant to Tamiflu

Tuesday 01 04 14 07:31 UTC
Tamiflu is one of the few available treatments for those who come down with the flu. But the virus quickly develops resistance; multiplying at a rate of several generations a day, these tiny pathogens rapidly accumulate genetic mutations. Because of this, they have a good chance of developing counterattacks to the antiviral. How can these infinitesimal variations be identified within the immensity of the virus' genetic code? EPFL researchers have created a computer tool that can shed light on the flu virus' formidable adaptability.

Preparing against Tamiflu-resistant influenza viruses

Wednesday 11 12 13 09:00 UTC
Researchers in Umea and Uppsala have found that residues of the influenza drug Tamiflu in our environment can make the influenza virus in birds resistant. This can have serious consequences in the event of an influenza pandemic.

Tamiflu-resistant swine flu on the rise - Irish Times

Tuesday 19 03 13 11:08 UTC

Tamiflu-resistant swine flu on the rise
Irish Times
Tamiflu-resistant swine flu is turning up in about 2 per cent of cases globally, researchers in Australia found, raising the risk that Tamiflu pill may become ineffective in fighting the pandemic H1N1 virus. Drug resistance in the flu strain that ...

Tamiflu resistant swine flu virus has experts worried - India.Com Health

Tuesday 19 03 13 07:18 UTC

Tamiflu resistant swine flu virus has experts worried
India.Com Health
Researchers in Australia have discovered that the Tamilflu – the most-effective drug against swine flu – might be losing its effect. While currently 2% of the swine flu strains are resistant to Tamiflu, the researchers found mutations in all the ...

Swine flu virus getting resistant to Tamiflu? - Times of India

Monday 18 03 13 23:41 UTC

Swine flu virus getting resistant to Tamiflu?
Times of India
MELBOURNE: Swine flu virus may be now resistant to key medicine Tamiflu, raising fears a new outbreak may be difficult to fight, Australian research has warned. While just 2% of swine flu (H1N1) strains around the world are resistant to Tamiflu, the ...

Swine flu becoming resistant to Tamiflu - GlobalPost

Monday 18 03 13 18:13 UTC

Swine flu becoming resistant to Tamiflu
GlobalPost
Tamiflu is one of the few treatments that can cure swine flu. But cases of swine flu that are resistant to Tamiflu are getting more common, researchers warn. Dr Aeron Hurt, an Australian researcher from the World Health Organization, found that ...

Swine Flu Becoming More Resistant To 'Tamiflu,' Scientists Say - Nature World News

Monday 18 03 13 16:47 UTC

Nature World News

Swine Flu Becoming More Resistant To 'Tamiflu,' Scientists Say
Nature World News
The swine flu appears to be more prone to developing drug resistance than other types of flu, said Dr. Aeron Hurt from the World Health Organization collaborating center for flu research in Melbourne, Australia. Research on patients in Newcastle, New ...

Swine flu cases resistant to Tamiflu are becoming more common, say scientists - The Guardian

Monday 18 03 13 14:52 UTC

The Guardian

Swine flu cases resistant to Tamiflu are becoming more common, say scientists
The Guardian
Tamiflu, generic name oseltamivir, is one of the few treatments available for pandemic swine flu, although it is thought to be of limited effectiveness. The reluctance of the manufacturer Roche to release all the trial data has made it difficult to ...

Swine flu strain resistant to Tamiflu is spreading more easily - Los Angeles Times

Wednesday 28 12 11 23:20 UTC

Los Angeles Times

Swine flu strain resistant to Tamiflu is spreading more easily
Los Angeles Times
The flu season is still young in the US and the rest of the Northern Hemisphere, but Australia wrapped up its flu season months ago, and public health officials there have some disturbing news to report: The version of so-called swine flu that is ...

Tamiflu-Resistant Flu Outbreak Reported in Australia's Newcastle, WHO Says - Bloomberg

Friday 26 08 11 03:37 UTC

Tamiflu-Resistant Flu Outbreak Reported in Australia's Newcastle, WHO Says
Bloomberg
More than two dozen cases of H1N1 swine flu resistant to Roche Holding AG (ROG)'s Tamiflu pill were reported in Australia in the largest outbreak of the drug- evading influenza strain. ...

WHO investigates Tamiflu resistance, updates antiviral recommendations for H1N1 patients with severely compromised immune systems

Friday 04 12 09 07:18 UTC
Following recent reports of clusters of Tamiflu resistance, the WHO on Wednesday recommended that patients with severely weakened immune systems who become infected with the H1N1 (swine flu) virus receive additional antiviral treatment as needed throughout the duration of their illness, Agence France-Presse reports. "

Swine flu: Strain resistant to Tamiflu spreads between UK hospital patients

Friday 20 11 09 19:20 UTC
A strain of Tamiflu-resistant swine flu has spread between hospital patients.

Person-to-person spread of Tamiflu-resistant strain of swine flu

Friday 20 11 09 18:23 UTC

Health officials in Wales say a strain of Tamiflu-resistant H1N1 swine flu has passed from person to person in a Cardiff hospital. The first news of this story was broken on this blog just a couple of hours ago. The National Public Health Service for Wales says that five patients at the University Hospital of Wales in Cardiff were all diagnosed with swine flu resistant to Tamiflu. All have severe underlying health conditions. Three appear to have acquired the infection in hospital.

We know that sporadic resistance to Tamiflu has developed in individuals being treated for swine flu. But this appears to be the first definite case in the world of person-to-person transmission of a Tamiflu-resistant strain. Another case reported in the United States by the CDC in September had a number of other possible explanations.

In truth it's not easy to be absolutely certain that there has been person-to-person transmission in Wales. Chris Lines, director of communications for Public Health Wales, said "we can't find any other explanation for this, so our confirmation of person-to-person spread is based on the lack of evidence of any other means of transmission."

He gave some more detail about the patients: "Of the five, two have recovered and been discharged having recovered. Of the three in hospital, one is in critical care and two are on the wards but being isolated from other patients."

So how important is this? Hopefully this will be a viral dead-end and it won't go any further. I'm told all the patients were immunocompromised and so especially vulnerable to developing Tamiflu resistance.

Dr Roland Salmon, director of the NPHS Communicable Disease Surveillance Centre, said: "The emergence of influenza A viruses that are resistant to Tamiflu is not unexpected in patients with serious underlying conditions and suppressed immune systems, who still test positive for the virus despite treatment."

Finally, just to stress, there's no evidence or suggestion that a "new" Tamiflu-resistant strain of H1N1 virus is now "out there" in the community. But public health officials in Wales will be very busy this weekend tracing contacts to ensure they have contained this among this small group of patients.

Tamiflu-resistant strain of swine flu spreading

Friday 20 11 09 17:56 UTC

Resistant strain discovered in Cardiff hospital, prompting concern among health officials

Doctors in Wales have discovered a Tamiflu-resistant strain of swine flu that has been spreading from patient to patient in a Cardiff hospital.

The emergence of an easily transmissible, resistant strain is a worrying development for health officials and appears to be the first documented case in Europe.

Five patients at University Hospital Wales, in Cardiff, were infected and isolated for treatment. All had severe underlying conditions that left them with weakened immune systems. At least three had acquired the infection in hospital.

There have been a handful of reported cases from around the world of Tamiflu-resistant strains of the H1N1 virus. Only one previous case, at a US summer camp, however, involved person-to-person transmission.

The Cardiff patients have been treated with an alternative anti-viral drug. Two have recovered and been discharged and three others remain in hospital, one in intensive care.

Dr Roland Salmon, the director of the communicable disease surveillance centre in Wales, said: "The emergence of [H1N1] viruses that are resistant to Tamiflu is not unexpected in patients with serious underlying conditions and suppressed immune systems, who still test positive for the virus despite treatment.

"In this case, the resistant strain of swine flu does not appear to be any more severe than the swine flu virus that has been circulating since April.

"For the vast majority of people, Tamiflu has proved effective in reducing the severity of illness. Vaccination remains the most effective tool we have in preventing swine flu so I urge people identified as being at risk to look out for their invitation to be vaccinated by their GP surgery."

Any spread of a Tamiflu-resistant strain of the virus into the community would constitute a serious public health concern. The government recently reminded those who caught swine flu to take Tamiflu as a first line of medical defence.

A Department of Health official in London said: "We take this development seriously, but the Health Protection Agency considers that the risk to the general healthy population is low. The Tamiflu-resistant virus has emerged in a group of particularly vulnerable individuals – this type of resistance is well documented.

"Our strategy to offer anti-virals to all patients with swine flu is the right one – to help prevent complications and reduce the severity of the illness. We are keeping the situation under review."

    HealthSwine flu
Owen Bowcott
guardian.co.uk © Guardian News & Media Limited 2009 | Use of this content is subject to our Terms & Conditions | More Feeds

Person-to-person spread of Tamiflu-resistant strain investigated

Friday 20 11 09 16:19 UTC

I am indebted to a loyal follower of this blog for tipping me off about a breaking news story in Wales.

Health officials in Cardiff are investigating the spread of a Tamiflu-resistant strain of swine flu at University Hospital Wales. The strain has infected a small number of patients, all of whom have serious underlying health conditions.

Roche, the maker of Tamiflu, tells me that there have been 57 cases worldwide of people developing resistance to Tamiflu while taking the drug (seven of these in the UK).

But what happened at University Hospital Wales may be quite different. Here, someone developed resistance - and then, I understand, this strain appears to have been passed from person to person in the hospital.

There's been only one other similar case in the United States between two people at a summer camp, but the resistant strain did not spread any further. The CDC reported on this in September.

Health officials in Wales tell me that more tests are being carried out to confirm exactly what happened, and they are not yet confirming person-to-person spread.

All the patients are said to be recovering and being cared for in controlled environments, so there is no risk to anyone else.

Tamiflu is an antiviral and can reduce the risk of the complications of flu, as well as shortening the duration of the illness. The UK has enough doses for half the population. Any spread of a Tamiflu-resistant strain of swine flu would be a serious public health concern - but there is no evidence to suggest that this has happened.

Obviously this is a developing story, and I'll bring you more when I get it.

Man contracts swine flu resistant to Tamiflu

Friday 11 09 09 16:56 UTC
A PERTH man has become the first person in Australia to contract a strain of swine flu which is resistant to the antiviral drug Tamiflu.

Tamiflu-resistant swine flu identified along Texas-Mexico border

Wednesday 05 08 09 00:53 UTC
PAHO on Monday announced it had found Tamiflu-resistant H1N1 (swine) flu along the Texas-Mexico border, Agence-France Press reports. The discovery of several cases in El Paso and McAllen, Texas, adds the U.S. to a growing list of countries with antiviral-resistant H1N1, such as Canada, Denmark, Hong Kong and Japan. "Experts had gathered in La Jolla on Monday to discuss the response to the outbreak, and warned that resistant strains were likely emerging because of overuse of antivirals like Tamiflu," the news service writes (8/3).

Swine flu could become resistant to Tamiflu because of over ... - Telegraph.co.uk

Tuesday 28 07 09 08:04 UTC

Telegraph.co.uk

Swine flu could become resistant to Tamiflu because of over ...

Could Tamiflu 'overkill' make swine flu resistant? - Daily Mail

Tuesday 28 07 09 03:42 UTC

Daily Mail

Could Tamiflu 'overkill' make swine flu resistant?
Daily Mail
The mass use of Tamiflu could leave Britain all but defenceless against swine flu, doctors have warned. Peter Holden, the British Medical ...

Swine flu could become resistant to Tamiflu because of overprescribing

Tuesday 28 07 09 01:27 UTC
Swine flu could become resistant to the only drug that can treat the virus because it is being overprescribed.

Tamiflu-Resistant Flu Found in Three World Regions, Health ... - Bloomberg

Thursday 09 07 09 21:55 UTC

Tamiflu-Resistant Flu Found in Three World Regions, Health ...

Experts Keep Wary Eye on Tamiflu-Resistant Swine Flu - U.S. News & World Report

Wednesday 08 07 09 22:06 UTC

VietNamNet Bridge

Experts Keep Wary Eye on Tamiflu-Resistant Swine Flu
U.S. News & World Report
WEDNESDAY, July 8 (HealthDay News) -- Health experts say they can't predict at this point how widely a new strain of swine flu resistant ...

WHO: Pandemic (H1N1) 2009 news brief: no. 1 -Viruses resistant to oseltamivir (Tamiflu) identified

Wednesday 08 07 09 22:00 UTC
WHO has been informed by health authorities in Denmark, Japan and the Special Administrative Region of Hong Kong, China of the appearance of H1N1 viruses which are resistant to the antiviral drug oseltamivir (known as Tamiflu) based on laboratory testing.

Swine Flu: the rise of anti-viral resistance - Times Online

Wednesday 08 07 09 18:45 UTC

Straits Times

Swine Flu: the rise of anti-viral resistance
Times Online
While much of the world's media obsesses about death tolls from the swine flu pandemic, more evidence has emerged today of what is arguably the more ...

Tamiflu-Resistant Swine Flu in US? - WebMD

Wednesday 08 07 09 17:58 UTC

Tamiflu-Resistant Swine Flu in US?
WebMD
A 16-year-old girl traveling from San Francisco was found to be infected with Tamiflu-resistant swine flu after triggering a ...

Viruses resistant to oseltamivir (Tamiflu) identified

Wednesday 08 07 09 16:20 UTC
8 July 2009 -- WHO has been informed by health authorities in Denmark, Japan and the Special Administrative Region of Hong Kong, China of the appearance of H1N1 viruses which are resistant to the antiviral drug oseltamivir (known as Tamiflu) based on laboratory testing.

Viruses resistant to oseltamivir (Tamiflu) identified

Wednesday 08 07 09 16:20 UTC
8 July 2009 -- WHO has been informed by health authorities in Denmark, Japan and the Special Administrative Region of Hong Kong, China of the appearance of H1N1 viruses which are resistant to the antiviral drug oseltamivir (known as Tamiflu) based on laboratory testing.

Tamiflu resistant swine flu case found in HK: govt - AFP

Friday 03 07 09 16:32 UTC

Straits Times

Tamiflu resistant swine flu case found in HK: govt
AFP
HONG KONG (AFP) — Hong Kong on Friday detected a strain of swine flu that was resistant to Tamiflu, the main anti-viral flu drug, the health department ...

Tamiflu-resistant swine flu patient found - Brisbane Times

Thursday 02 07 09 22:31 UTC

Straits Times

Tamiflu-resistant swine flu patient found
Brisbane Times
TOKYO - A genetic mutation of swine flu that is resistant to the antiviral Tamiflu has been discovered in Japan, the first such case in the country, ...

Tamiflu-resistant swine flu patient found in Japan: govt - AFP

Thursday 02 07 09 22:17 UTC

Malaysia Star

Tamiflu-resistant swine flu patient found in Japan: govt
AFP
TOKYO (AFP) — A genetic mutation of swine flu that is resistant to the anti-viral Tamiflu has been discovered in Japan, the first such case in the country, ...
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